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CMF (cyclophosphamide, methotrexate and 5-fluorouracil)

If you have CMF, you'll have a total of six cycles of treatment. Each cycle lasts 14 days and is repeated every 4 weeks. So that's a total of six months of treatment.
On days 1 and 8 of each cycle you'll have an injection of methotrexate and 5-fluorouracil (also called 5-FU) at the out-patient clinic. You can have an injection of cyclophosphamide at the same time, or you can take a cyclophosphamide tablet each day for the first 14 days of each cycle.

Main side effects

  • Nausea
  • Tiredness
  • Mouth ulcers
  • Infections
  • Diarrhoea
  • Some hair loss
  • Loss of fertility
A lot can be done to relieve these problems. See dealing with chemotherapy side effects.

To find out more about this treatment, try the CancerBACUP website.

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