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FEC (5-fluorouracil, epirubicin, cyclophosphamide)

If you have FEC, you'll have four to six cycles of treatment, and each cycle is given once every 3-4 weeks. That's a total of 12-24 weeks of treatment.
The treatment given can be either:

  • On days 1 and 8 of each four week cycle you'll have injections of epirubicin and 5-fluorouracil (5-FU). You'll also take a cyclophosphamide tablet each day for the first 14 days of the cycle.
  • Alternatively, on day 1 of each three-week cycle you'll have injections of epirubicin, 5-fluorouracil (5-FU) and cyclophosphamide.

FEC includes epirubicin - one of a group of drugs called anthracyclines. There is evidence that chemotherapy which includes an anthracycline works better than CMF but anthracyclines tend to have more severe side effects.

Main side effects

  • Nausea and vomiting
  • Tiredness
  • Mouth ulcers
  • Diarrhoea
  • Infections
  • Complete loss of hair
  • Itchy rash and nail changes
  • Bladder irritation
  • Loss of fertility
A lot can be done to relieve these problems. See dealing with chemotherapy side effects.

To find out more about this treatment, try the CancerBACUP website.

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